Figure 5.

Persistent and long-term cerebral hypoperfusion, WMI and cognitive impairment at 24 weeks in the needle ABCS model. A, Two-dimensional laser speckle image of brain perfusion in needle mice 24 weeks after surgery. B, DEC map of ex vivo DTI in needle mice 24 weeks after surgery. C, LFB staining. * denotes microinfarct. D, Rotarod test. E, F, Spatial learning and memory in water maze test 24 weeks after the surgery. G, Passive avoidance test. H, NOR test. Data were expressed as mean ± SEM, *p < 0.05 needle versus sham; **p < 0.01 versus sham, two-way ANOVA and Neuman–Keuls post hoc. n = 12 for sham, n = 13 for needle groups.