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. Author manuscript; available in PMC: 2023 Nov 2.
Published in final edited form as: Cell Rep. 2023 Aug 30;42(9):113046. doi: 10.1016/j.celrep.2023.113046

Figure 2. RNA sequencing across cell types and fALS mutations.

Figure 2.

CRISPR editing strategy to generate heterozygous fALS mutations sharing the same genetic background.

(B) Differentiation of edited iPSCs.

(C) Heatmap for selected cell markers (n = 3 libraries per condition).

(D) Volcano plots comparing all control lines vs. all ALS lines.

(E) Differentially expressed genes due to fALS mutations across different cell types.

(F) Comparison of differentially expressed genes in fALS iPSC LMNs with laser-captured LMNs from postmortem sALS samples32 (n = 8 postmortem control and n = 13 postmortem sALS spinal cords).