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. Author manuscript; available in PMC: 2023 Nov 2.
Published in final edited form as: Cell Rep. 2023 Aug 30;42(9):113046. doi: 10.1016/j.celrep.2023.113046

Figure 3. Alternatively spliced genes in TDP-43-depleted FTD-ALS postmortem neurons are downregulated in iPSC LMNs.

Figure 3.

(A) 61 genes are differentially spliced in postmortem neurons that are depleted for TDP-4312,13 and have sufficient read counts to analyze in iPSC LMNs. Those genes are plotted for each cell type and fALS mutation combination. p values were calculated using gene set enrichment analysis (GSEA).

(B) STMN2 splicing in the TARDBP LMN isogenic pair, TDP-43 knockdown,12 and sALS postmortem LMNs.32 Black arrows indicate exon 2a.

(C) Expression of splicing genes in C9ORF72 iPSC LMNs.40 Significant genes are colored in red; n = 6 libraries per condition.

(D) STMN2 splicing in C9ORF72 iPSC LMNs.

(E) Expression of splicing genes in SOD1A4V/+ iPSC LMNs.41 Significant genes are colored in red; n = 3 control libraries and n = 2 SOD1A4V/+ libraries.