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. 2023 Nov 2;14:6801. doi: 10.1038/s41467-023-42626-3

Fig. 2. Glial cell-enriched gene co-expression network modules are associated with PSP.

Fig. 2

a The associations between the module eigengenes (ME) and PSP diagnosis or quantitative tau neuropathology were assessed. b Enrichment of cell type specific genes was detected in seven modules, three of which (M3=oligodendrocyte, M4=astrocyte, and M6=microglia/endothelia) were significantly associated with PSP. Statistics: one-sided Fisher’s Exact Test. Unadjusted p values are provided in Supplementary Data 2 and source data. c Associations were robust and consistent across both studies and significant in the consensus network modules M3, M4, M6. Statistics: two-sided t-test comparing PSP and control module eigengenes. Bonferroni-adjusted p values are presented. Study 1: N = 257 PSP and Control individuals; Study 2: N = 151 PSP and Control individuals; Combined: N = 408 PSP and Control individuals. Also see Supplementary Table 1. d Top enriched gene ontology biological process terms in the PSP-associated glial cell-enriched modules. Source data are provided as a Source Data file.