Table 2.
Summary measures of EED and systemic inflammation biomarker concentrations overall by child age and sex
| Variable | Biomarker in stool | Biomarker in serum | |||||
|---|---|---|---|---|---|---|---|
| n | MPO, ng/mL; median (IQR) | AAT, μg/mL; median (IQR) | NEO, nmol/L; median (IQR) | n | CRP, mg/L; median (IQR) | AGP, g/L; median (IQR) | |
| Overall | 574 | 23,233 (9,481–55,227) | 422 (233–720) | 1,534 (753–3,089) | 428 | 0.62 (0.14–2.42) | 0.77 (0.58–1.11) |
| Child age, months | |||||||
| 0–5 | 79 | 39,686 (21,105–92,967) | 455 (228–731) | 1,920 (1,265–3,412) | * | * | * |
| 6–11 | 179 | 28,691 (12,746–56,629) | 425 (232–707) | 2,064 (1,175–3,441) | 148 | 0.84 (0.17–2.86) | 0.84 (0.59–1.18) |
| 12–17 | 134 | 21,740 (8,194–44,635) | 398 (225–654) | 1,367 (701–2,718) | 119 | 0.61 (0.10–2.0) | 0.73 (0.58–1.09) |
| 18–24 | 182 | 17,170 (6,701–39,899) | 412 (246–747) | 922 (395–1,872) | 161 | 0.51 (0.09–2.02) | 0.75 (0.57–1.01) |
| Child sex | |||||||
| Male | 312 | 22,935 (8,841–53,546) | 399 (216–669) | 1,557 (795–3,126) | 230 | 0.69 (0.17–2.25) | 0.78 (0.59–1.08) |
| Female | 262 | 23,323 (10,472–57,474) | 454 (262–788) | 1,455 (717–2,956) | 198 | 0.55 (0.12–2.56) | 0.76 (0.57–1.14) |
AAT = alpha-1-antitrypsin; AGP = alpha-1-acid glycoprotein; CRP = C-reactive protein; EED = environmental enteric dysfunction; IQR = interquartile range; MPO = myeloperoxidase; NEO = neopterin.
*
Serum was not collected from children younger than 6 months of age.