Fig. 3.

Relationship between HBV/HDV genotype combination, HDAg positivity, and in vitro sensitivity to BLV in laboratory strains.

(A) Median BLV EC₅₀ values for HDV-1 enveloped with representative sequences of HBV PreS1 GTA–D (stars) or the most common polymorphisms found in clinical samples. Each data point represents the average of two independent experiments. Bars show median values. (B) Median BLV EC₅₀ values vs. percentage of HDAg-positive cells for HDV-1 enveloped with representative sequences of HBV PreS1 GTA–D (stars) or the most common polymorphisms found in clinical samples. Each data point represents the average of two independent experiments. Bars show median values. (C) Median BLV EC₅₀ values as a function of the percentage of HDAg-positive cells for all HBV/HDV combinations tested. Each data point represents the average of at least two independent experiments. Bars show median values. BLV, bulevirtide; GTA–H, genotypes A–H; HDAg, HDV antigen; HDV-1, HDV genotype 1.