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. 2023 Sep 4;299(10):105226. doi: 10.1016/j.jbc.2023.105226

Figure 5.

Figure 5

Klf15KO muscles decrease cell differentiation and metabolic processes.A, the transcription expression profiling of TA muscle from WT and Klf15KO mice at day 7 after CTX injection were accessed by RNA-seq (n = 3). B, the scatter plot showing differentially expressed genes (DEGs). C and D, functional annotations of upregulated and downregulated genes in Klf15KO mice, respectively. E, heatmap of genes upregulated in Klf15KO muscle related to collagen, extracellular region, and innate immune response. F, heatmap of genes downregulated in Klf15KO muscle related to metabolism and cell differentiation. G, qRT-PCR verified the mRNA levels of the candidate genes categorized into metabolism and cell differentiation in WT and Klf15KO muscles at day 7 postinjury (n = 6, ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p< 0.001, unpaired student t test). CTX, cardiotoxin; KLF15, Krüppel-like factor 15; qRT-PCR, quantitative real-time PCR.