. 2023 Oct 2;6:100213. doi: 10.1016/j.ijpx.2023.100213

Table 2.

In-vitro release testing of RSNP Formulations.^⁎

Formulation Code^⁎	Amount Released (%)		Release Model
	Q_24h	Q_4w	Zero	Diffusion	Korsmeyer-Peppas
	Q_24h	Q_4w	r²	r²	r²	k	n
RSNP1	30.13 $\pm$ 0.40	95.31 $\pm$ 1.67	0.859 $\pm$ 0.007	0.971 $\pm$ 0.001	0.984 $\pm$ 0.006	7.298 $\pm$ 0.027	0.404 $\pm$ 0.002
RSNP2	27.29 $\pm$ 2.36	98.72 $\pm$ 0.52	0.891 $\pm$ 0.002	0.984 $\pm$ 0.002	0.987 $\pm$ 0.005	6.730 $\pm$ 0.108	0.417 $\pm$ 0.004
RSNP3	32.00 $\pm$ 2.44	90.52 $\pm$ 1.22	0.869 $\pm$ 0.011	0.974 $\pm$ 0.007	0.989 $\pm$ 0.003	10.000 $\pm$ 2.353	0.343 $\pm$ 0.043
RSNP4	32.67 $\pm$ 1.75	96.61 $\pm$ 0.36	0.877 $\pm$ 0.008	0.971 $\pm$ 0.005	0.972 $\pm$ 0.018	9.369 $\pm$ 0.458	0.358 $\pm$ 0.010
RSNP5	28.59 $\pm$ 0.58	86.28 $\pm$ 9.47	0.866 $\pm$ 0.007	0.976 $\pm$ 0.004	0.976 $\pm$ 0.003	10.170 $\pm$ 1.224	0.334 $\pm$ 0.005
RSNP6	31.18 $\pm$ 0.16	89.92 $\pm$ 1.58	0.826 $\pm$ 0.018	0.956 $\pm$ 0.007	0.978 $\pm$ 0.001	9.827 $\pm$ 0.070	0.351 $\pm$ 0.005
AL-RSNP	22.56 $\pm$ 2.11	81.52 $\pm$ 4.81	0.842 $\pm$ 0.013	0.968 $\pm$ 0.005	0.986 $\pm$ 0.004	6.399 $\pm$ 0.106	0.408 $\pm$ 0.006

Abbreviations: RSNP, Rosuvastatin-entrapped silica nanoparticles; AL-RSNP, Alginate-loaded rosuvastatin-entrapped silica nanoparticles; Q_24h, % drug released after 24 h; Q_4w, % drug released after 4 weeks.

^⁎

The composition of the prepared RSNP is found in Table 1. AL-RSNP is composed of Alginate matrix loaded with the selected Rosuvastatin-entrapped silica nanoparticle (RSNP2).