Fig. 5.

HERV-specific pathway analysis. Heatmaps that show the results of the HERV-specific pathway analysis for the aggressive (A) and indolent (B) forms of CLL. In detail, the columns are the enriched pathways while the rows are the differentially expressed HERVs. The values plotted in the heatmap are the “corrected accumulators” generated by MITHrIL as an indicator of the magnitude of pathway dysregulation. Corrected accumulator values with an associated not statistically significant P-value have been assigned the value 0 and plotted with the color white in the heatmaps.