Fig. 5.

Clozapine fails to promote an antioxidant effect in the intramitochondrial compartment in U937 cells.

U937 cells were treated for 1 h (A and C) or 24 h (B and D) with or without CLZ and then exposed for 10 min to 100 μM ATP/2.5 μM arsenite. Cells were finally analysed for ROS formation with either MitoSOX-red (A and B) or DCF (C and D). CTR samples received DMSO alone. Data are expressed as % of untreated CTR cells. Results represent the means ± SEM calculated from at least three independent determinations. **p < 0.01 as compared to CTR cells; ns: not significant (Unpaired t-test). (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)