Fig. 9.

Schematic summary shows the proposed recruitment of the ‘vCA1-pBLA circuit’ in GRov mice following optogenetic stimulation in the vDG, resulting in a greater emotional reactivity which was evident from both the greater amplitude and longer duration of the approach behavior in GRov mice in the EPM. At molecular level, distinct subpopulations of the glutamatergic system (Vglut1⁺) in hippocampal-amygdala circuit (Vglut1⁺/Calbn1⁺ in vCA1 (yellow circles) and Vglut1⁺/Ppp1r1b⁺ in pBLA (magenta circles)) were predominantly modified in the stress system and might directly contribute to the observed amplified emotional lability in GRov mice upon the vDG activation.