Figure 12.

Hypoxia in oncology. (a) Three regions around a blood vessel in a tumor. Image courtesy Iris Kort. (b) Association between tumor hypoxia and overall survival in advanced cancer of the uterine cervix. Reprinted with permission from Vaupel et al., Association between Tumor Hypoxia and Malignant Progression in Advanced Cancer of the Uterine Cervix. Cancer Res., 1996, 56, 4509–4515. Copyright 1996 American Association for Cancer Research. (c) Clinical response to 5-ALA PDT treatment in tongue/floor of mouth tumor patients. Reproduced with permission from Busch et al., Lesion oxygenation associates with clinical outcomes in premalignant and early stage head and neck tumors treated on a phase 1 trial of photodynamic therapy. Photodiagnosis Photodynamic Therapy2018, 21, 28–35. Copyright 2018 Elsevier.