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. 2023 Nov 3;18:72. doi: 10.1186/s13062-023-00424-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Bulk data combined with single-cell data to identify LYPD3 as a study subject. A Co-expression network constructed based on DEGs between C1 and C2. B, C The Multiscale Embedded Gene co-expression Network Analysis (MEGENA) network shows the two largest gene modules. Different colors represent genes in different modules, and triangles represent hub genes in the modules. D GO and KEGG functional enrichment analysis demonstrated shared and unique biological signals of C1_3 and C1_4. E Violin plots show the expression of hub genes in C1_3 and C1_4 across 6 cell types in GSE189889. F UMAP plot showing the expression levels of LYPD3, defined for six cell types. G–I The forest map shows the results of Cox regression analysis on the OS (G), Disease Specific survival (DSS, H), and Progrssion Fre Interval (PFI, I) of 10 hub genes in the TCGA-SKCM cohort