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. 2023 Nov 3;18:72. doi: 10.1186/s13062-023-00424-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — High-dimension Weighted Correlation Network Analysis (hdWGCNA) of melanoma cell reveals the crucial roles of C1. A Dendrogram demonstrating nine gene modules in the scale-free network. B Nine gene modules and the associated top 10 hub gene were displayed according to the hdWGCNA pipeline. C Correlation between nine gene modules. Green represents negative correlation and purple represents positive correlation. D Nine module levels in different melanoma cell clusters. E Violin plot demonstrating that Module 1 (M1) activity is significantly higher in Cluster 1 than in the other melanoma cell clusters. F Protein–protein interaction (PPI) network for the top 25 genes in M1. G GO and KEGG enrichmnt analysis of M1. H Expression level of M1 hub genes between melanoma tissues in the TCGA-SKCM cohort (n = 469) and control tissues in in both the TCGA and GTEx databases (n = 813). Wilcoxon test, ***P < 0.05. I Forest plot showing the results of Cox regression analysis of the mean survival (overall survival) of the 10 M1 hub genes in the TCGA-SKCM cohort. J–K All cell types were analyzed by Cellchat and melanoma cells were classified according to stemness level as cluster 1 (high), cluster 0 (low), and other melanoma cells (medium). The results showed both interaction numbers and interaction strengths. L–O Cellchat analysis showed weaker communication strength between melanoma cell cluster 1 and T cells compared to melanoma cell cluster 0