Table 1.
Clinical trials targeting CD24 registered with the National Clinical Trials Registry (NCT) system
| NCT ID | Phase | Treatment | Malignancy type | Enrollment | Endpoints | Locations | Current Status |
|---|---|---|---|---|---|---|---|
| NCT04060407 | 1b/2 | CINDI | Metastatic Melanoma | 0 | Business Reasons | Huntsman Cancer Institute, Salt Lake City, Utah, USA | Withdrawn |
| NCT04552704 | 1/2 | TIRAEC | Advanced Malignant Solid Neoplasm | 3 | Sponsor Change |
University of California Davis Comprehensive Cancer Center Sacramento, California, USA |
Terminated |
| NCT04095858 | 3 | CD24Fc/tacrolimus / methotrexate (CD24Fc/Tac/MTX) |
Hematopoietic Stem Cell Transplantation Acute Graft Versus Host Disease Acute Myeloid Leukemia Acute Lymphoblastic Leukemia Myelodysplastic Syndromes |
11 | Business Reasons |
City of Hope (Site 0302), Duarte, California, USA The University of Chicago Medical Center (Site 0306), Chicago, Illinois, USA Penn State University Milton S. Hershey Medical Center (Site 0304), Hershey, Pennsylvania, USA Abramson Cancer Center of the University of Pennsylvania (Site 0309), Philadelphia, Pennsylvania, USA |
Terminated |
| NCT02663622 | 2 | Phase II Trial of CD24Fc for the Prevention of Acute GVHD Following Myeloablative Allogeneic HSCT (MK-7110–002) |
Graft Versus Host Disease Hematopoietic Stem Cell Transplantation Leukemia |
44 |
Indiana University School of Medicine, Indianapolis, Indiana, USA The University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, USA Karmanos Cancer Institute, Detroit, Michigan, USA Ohio State University, Columbus, Ohio, USA |
Completed | |
| NCT01214512 | Not Provided | Performance Evaluation of the Micromedic CD24 in Vitro Diagnostic Assay | Colorectal Cancer | 229 | Not Provided |
Bat Yamon Gastroentrology Clinic, Bat Yam, Israel Zamenhoff Gastroentrology Clinic, Tel Aviv, Israel |
Completed |
| NCT01265225 | Not Provided | Prognostic Value of Stem Cell Related Markers | Breast Cancer | 0 | No Finance | Baruch PMC, Poriya, Lower galilee, Israel | Withdrawn |
| NCT04907422 | Not Provided | Diagnostic and Prognostic Accuracy of Gold Nanoparticles in Salivary Gland Tumours |
Carcinoma Ex Pleomorphic Adenoma of Salivary Glands Pleomorphic Adenoma of Salivary Glands |
60 | Not Provided | Faculty of Dentistry, October 6 University, Giza, Egypt | Completed |
Abbreviations: CINDI CD24Fc With Ipilimumab and Nivolumab to Decrease irAE, TIRAEC Treatment of Immune Related Adverse Events in Patients with CD24Fc, GVHD Graft Versus Host Disease