Fig. 3.

Construction and validation of a prognostic nomogram A Univariate Cox regression analysis suggested that SLC7A11 and clinically relevant factors (clinical stage, T stage, and M stage) are prognostic factors. B Multivariate Cox regression analysis suggested that SLC7A11 and T stage are independent clinical characteristics for overall survival prediction. C Nomogram for overall survival prediction, with sex, age, N-stage, clinical stage, T-stage, and the expression level of SLC7A11 applied as parameters. D Calibration curves of the nomogram for 1-, 3-, and 5-year overall survival prediction. E DCA evaluated the clinical practicability of the model and calculated the clinical benefit rate of the model. F Time-dependent receiver operating characteristic curves of the predictive value of the nomogram risk score for overall survival: 1-year AUC = 0.743, 3-year AUC = 0.952, and 5-year AUC = 0.950. G Time-dependent receiver operating characteristic curves of the predictive value of SLC7A11 for overall survival: 1-year AUC = 0.635, 3-year AUC = 0.777, and 5-year AUC = 0.781