Fig. 6.

Correlation between SLC7A11 and immune infiltration A Overall infiltration of 22 immune cells in ACC. B The CIBERSORT algorithm revealed that the infiltration levels of activated dendritic cells were increased in the high SLC7A11 expression group, while the infiltration levels of resting mast cells were decreased in the same group. C The Xcell algorithm revealed that the infiltration levels of Th2 cells and pro B cells were increased in the high SLC7A11 expression group, while the infiltration levels of B cells, cd4 + Tcms, CD8 + naive T cells, chondrocytes, class-switched memory B cells, eosinophils and ly endothelial cells were decreased in the same group. D SLC7A11 expression was positively correlated with the immune chemokines CXCL8, CXCL3, and CCL20 and negatively correlated with the immune chemokines CCL14 and CXCL17. E SLC7A11 expression was positively correlated with immune checkpoint genes (NRP1, TNFSF4, CD276, TNFRSF9). F SLC7A11 expression was positively correlated with tumour mutation burden. *P value < 0.05, **P value < 0.01, ***P value < 0.001