Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jun 15;35:1533317520927169. doi: 10.1177/1533317520927169

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

PMC Copyright notice

Figure 1. — A multistep process of bone marrow–derived microglia (BMDM) recruitment into brain in Alzheimer’s disease (AD). With stimulation of amyloid β (Aβ), the recruitment of BMDM is enhanced. CC-chemokine ligand 2 (CCL2) is produced by brain cells. CC-chemokine receptor 2 (CCR2)/CCL2 is necessary for cells engraftment from bone marrow into blood. Chemokine (C-X-Cmotif) ligand 1 (CXCL1), after binding with CXC chemokine receptor 2 (CXCR2) in human brain microvascular endothelial cells, derives transendothelial migration of bone morrow–derived cells and stromal-derived factor 1 (SDF-1)/ CXC chemokine receptor 4 (CXCR4) controls the trafficking of monocytes into the brain parenchyma.