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. 2019 Oct 24;35:1533317519883496. doi: 10.1177/1533317519883496

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© The Author(s) 2019

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 4. — The expression of TrkA in SH-SY5Y cells with simultaneously or singly silenced HDAC1, 2, and/or 3. The small-interfering RNA (siRNA) duplex was used to simultaneously interfere with the expression of endogenous HDAC1, 2, and 3 (A-C) or singly interfere with the expression of endogenous HDAC1 (D-F), HDAC2 (G-I), or HDAC3 (J-L). The untreated (non-siRNA) and nonspecific siRNA-treated (scrambled siRNA) cells were used as controls. The relative expression levels of TrkA messenger RNA and protein in cells were analyzed by quantitative real-time-polymerase chain reaction and Western blot, respectively. (n = 6; mean ± standard deviation; one-way analysis of variance followed by least significant difference multiple comparison tests; ***P < .001 vs control).