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. Author manuscript; available in PMC: 2024 Sep 1.
Published in final edited form as: Curr Protoc. 2023 Sep;3(9):e839. doi: 10.1002/cpz1.839

Figure 2.12.3.

Figure 2.12.3

Arrestin-3-mediated JNK1/2 activation by MKK4/7. In vitro phosphorylation of JNK1α1 and JNK2α2 in the presence of MKK4 (A) or MKK7 (B) yielded bell-shaped curves as functions of arrestin-3 concentration. Means ± SD of three independent experiments are shown. ANOVA analysis with arrestin-3 as main factor demonstrated significance of arrestin-3 concentration in the presence of MKK4 and MKK7 for both JNK1α1 and JNK2α2 (p < 0.001). * –p <0.001, ** –p <0.01, * –p <0.05 to maximal values (at 5 or 10 μM of arrestin-3, respectively) according to Bonferroni/Dunn post-hoc test with correction for multiple comparisons. Data from Kook et al. (2014).