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. 2023 Oct 31;14:910–918. doi: 10.18632/oncotarget.28534

Figure 3. Impact of FAAH inhibitors and exogenous cannabinoids on breast cancer cell viability.

Figure 3

(A, B) Cell viability assays were conducted using the FAAH inhibitors, PF750 and URB597, with the following treatments: vehicle control (cells with media and DMSO), 10 μM concentration, 30 μM concentration, and 50 μM concentration. (C, D) Cell viability was also measured for combination treatment of FAAH inhibitors with exogenous cannabinoids (URB597 with AEA and URB597 with PEA). For the combination treatments, assays included a vehicle control (cells with media and DMSO), 10 μM URB597 and 30 μM AEA/PEA, 30 μM URB597 and 10 μM AEA/PEA, 30 μM URB597 and 30 μM AEA/PEA, 50 μM URB597 and 10 μM AEA, and 50 μM URB597 and 30 μM AEA. Statistical significance was determined using a non-parametric Mann-Whitney U-test (*ρ < 0.05; N = 3–6 each).