Table 2.
β Coefficients and 95% CIs for the Association of MF and Its Subcomponents With the Changes of Global Cognitive Function and Cognitive Function in Specific Domains Over Follow-up Time: Results From Multiadjusted Linear Mixed-Effects Modelsa (n = 1,618)
| MF× time2 | Global cognition | Episodic memory | Semantic memory | Working memory | Visuospatial ability | Perceptual speed |
| Global MF | ||||||
| Continuous | 0.008b (0.007 to 0.010) | 0.009b (0.007 to 0.011) | 0.010b (0.008 to 0.011) | 0.009b (0.007 to 0.010) | 0.006b (0.004 to 0.008) | 0.010b (0.008 to 0.012) |
| Categories | ||||||
| High | Reference | Reference | Reference | Reference | Reference | Reference |
| Moderate | −0.002b (−0.003 to −0.002) | −0.003b (−0.004 to −0.002) | −0.003b (−0.003 to −0.002) | −0.002b (−0.003 to −0.001) | −0.002b (−0.003 to −0.001) | −0.003b (−0.004 to −0.003) |
| Low | −0.005b (−0.006 to −0.005) | −0.006b (−0.007 to −0.004) | −0.005b (−0.007 to −0.004) | −0.005b (−0.006 to −0.004) | −0.003b (−0.004 to −0.002) | −0.006b (−0.007 to −0.005) |
| Motor dexterity | ||||||
| Continuous | 0.008b (0.006 to 0.010) | 0.008b (0.005 to 0.010) | 0.010b (0.007 to 0.013) | 0.011b (0.008 to 0.014) | 0.008b (0.005 to 0.011) | 0.015b (0.012 to 0.018) |
| Categories | ||||||
| High | Reference | Reference | Reference | Reference | Reference | Reference |
| Moderate | −0.001b (−0.002 to −0.001) | −0.001b (−0.002 to −0.000) | −0.001b (−0.002 to −0.000) | −0.002b (−0.003 to −0.001) | −0.001b (−0.002 to −0.000) | −0.003b (−0.004 to −0.003) |
| Low | −0.004b (−0.005 to −0.003) | −0.004b (−0.005 to −0.003) | −0.004b (−0.005 to −0.002) | −0.004b (−0.005 to −0.003) | −0.003b (−0.004 to −0.002) | −0.006b (−0.007 to −0.004) |
| Motor gait | ||||||
| Continuous | 0.004b (0.003 to 0.006) | 0.004b (0.003 to 0.006) | 0.005b (0.003 to 0.006) | 0.005b (0.004 to 0.007) | 0.002b (0.000 to 0.004) | 0.004b (0.002 to 0.006) |
| Categories | ||||||
| High | Reference | Reference | Reference | Reference | Reference | Reference |
| Moderate | −0.001b (−0.001 to −0.000) | −0.000 (−0.001 to 0.001) | −0.001b (−0.002 to −0.000) | −0.001b (−0.002 to −0.000) | −0.000 (−0.001 to 0.001) | −0.000 (−0.001 to 0.001) |
| Low | −0.005b (−0.006 to −0.004) | −0.005b (−0.006 to −0.004) | −0.004b (−0.005 to −0.003) | −0.005b (−0.006 to −0.003) | −0.002b (−0.003 to −0.001) | −0.004b (−0.005 to −0.003) |
| Hand strength | ||||||
| Continuous | 0.006b (0.005 to 0.007) | 0.007b (0.006 to 0.009) | 0.007b (0.005 to 0.008) | 0.006b (0.004 to 0.007) | 0.005b (0.003 to 0.006) | 0.007b (0.006 to 0.009) |
| Categories | ||||||
| High | Reference | Reference | Reference | Reference | Reference | Reference |
| Moderate | −0.003b (−0.003 to −0.002) | −0.003b (−0.005 to −0.002) | −0.003b (−0.004 to −0.002) | −0.002b (−0.003 to −0.001) | −0.002b (−0.003 to −0.001) | −0.003b (−0.004 to −0.002) |
| Low | −0.004b (−0.005 to −0.003) | −0.005b (−0.007 to −0.004) | −0.005b (−0.006 to −0.004) | −0.004b (−0.005 to −0.002) | −0.003b (−0.004 to −0.002) | −0.005b (−0.006 to −0.003) |
Abbreviations: BMI = body mass index; MF = motor function.
Missing data: APOE ε4 genotype = 252; BMI = 9; depression = 7; stroke = 113.
a
Model adjusted for age, sex, education, BMI, APOE ε4, alcohol consumption, smoking, physical activity, social activity, hypertension, diabetes, heart disease, stroke, and depression.
b
p < 0.05.