Table 3.
β Coefficients and 95% CIs for the Association of Global MF at Baseline With Regional Brain Volumes on MRI: Results From Linear Regression Modelsa (n = 344)
| Regional brain volumes (mm3) | Continuous MF | MF categories | |
| Moderate vs high | Low vs high | ||
| Total brain | 50.995c (12.561 to 89.430) | −6.883 (−22.519 to 8.753) | −25.848c (−44.902 to −6.795) |
| Total gray matter | 25.247 (−4.007 to 54.502) | 2.800 (−9.112 to 14.711) | −9.221 (−23.735 to 5.294) |
| Cerebellar gray matter | 3.579 (−1.571 to 8.730) | 0.164 (−1.931 to 2.260) | −1.624 (−4.178 to 0.930) |
| Cortical gray matter | 17.281 (−3.301 to 37.863) | 2.322 (−6.056 to 10.700) | −6.136 (−16.345 to 4.074) |
| Subcortical gray matter | 4.387 (−3.027 to 11.802) | 0.313 (−2.708 to 3.335) | −1.461 (−5.143 to 2.221) |
| Hippocampal | 0.316 (−0.177 to 0.809) | 0.034 (−0.166 to 0.235) | −0.140 (−0.384 to 0.105) |
| Total white matter | 29.327 (−1.089 to 59.743) | −9.519 (−21.849 to 2.812) | −18.252c (−33.277 to −3.226) |
| Cerebellar white matter | 0.299 (−1.549 to 2.148) | 0.239 (−0.507 to 0.985) | −0.748 (−1.657 to 0.160) |
| Cortical white matter | 29.028 (−0.741 to 58.797) | −9.757 (−21.831 to 2.316) | −17.503c (−32.215 to −2.792) |
| White matter hyperintensitiesb | −0.476c (−0.758 to −0.194) | 0.130c (0.015 to 0.244) | 0.257c (0.118 to 0.397) |
Abbreviations: BMI = body mass index; MF = motor function.
Missing data: BMI = 3; depression = 4; stroke = 66.
a
Model adjusted for age, sex, education, BMI, APOE ε4, alcohol consumption, smoking, physical activity, social activity, hypertension, diabetes, heart disease, stroke, and depression.
b
The volume of white matter hyperintensities was transformed by taking the logarithm.
c
p < 0.05.