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. 2023 Oct 4;37(11):2150–2167. doi: 10.1038/s41375-023-02048-y

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Fig. 4 — IS values are expressed as percentages and/or molecular response (MR) levels relative to the IRIS standardized baseline. Testing laboratories use either (i) RT-qPCR or RT-dPCR to measure the ratio of BCR::ABL1 mRNA to that of a reference gene (ABL1, GUSB, BCR) and convert to the IS by multiplying the raw result by a laboratory-specific conversion factors (CF), or (ii) a validated kit/system that directly outputs results on the IS.