Figure 7. Precision targeting and antifungal killing on murine mucosa using dabbing nanozyme-microrobots.

(A) Explant of murine oral mucosal tissue harvested from the palate. (B) Focal C. albicans infection developed on the oral mucosa characterized by localized hyphal accumulation. (C) A schematic diagram of the coordinate extraction and precision-guided treatment using the dabbing nanozyme microrobot. (D) Bright field images showing sequential nanozyme dabbing. (E) Fluorescence imaging shows high spatial precision for targeting the site of fungal infection. (F) Cell viability counts show effective killing of targeted fungal cells on mucosa via catalytic activation of H₂O₂ on site. Data are mean ± standard deviation; ** P< 0.01, *** P < 0.001 by one-way analysis of variance with Tukey’s multiple-comparison test (n=8), and n.d. stands for not detectable.