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. 2023 Nov 3;14:7062. doi: 10.1038/s41467-023-42440-x

Fig. 3. Inhaled aerosolized anti-SARS-CoV-2 mAb treatment blocks SARS-CoV-2 replication in lung tissues and limits viral spread.

Fig. 3

a Graphical depiction of lung anatomy (upper left) and SARS-CoV-2 RNA detection levels in respiratory tract tissues. The graded scale shows the average relative copy number for each group (n = 4/group). Caudal lobes consistently have the highest level of virus detection across groups, but the SARS-CoV-2 mAb therapy reduces viral RNA levels relative to the control RSV mAb. b–e RNA was extracted from respiratory tract, heart and spinal cord tissues, and viral RNA levels were determined by qRT-PCR using SARS-CoV-2 specific primers and probes. Individual data points for each animal within each group (n = 4 biologically independent animals per group) are shown as are the mean and SEM for each group. Colors in the graphs are: solid red, Control Pre-Exp group; solid blue, SARS-CoV-2 Pre-Exp group; open red, Control Post-Exp group; gray, SARS-CoV-2 Post-Exp group; and solid green, SARS-CoV-2 Pre/Post-Exp group. Source data are provided as a Source Data file.