Table 2.
Associations between clinicopathological variables in METABRIC and immune cell clusters.
| Clinicopathological variable | Immune cell subtype clusters | p value* | ||
|---|---|---|---|---|
| Cluster A, n = 1113 (83.2%) | Cluster B, n = 224 (16.8%) | Total n = 1337 | ||
| Mean age (SD) | 59.4 (13.1) | 59.8 (13.2) | 59.4 (13.1) | 0.67 |
| Age group | 0.91 | |||
| < 60 years | 556 (50.0) | 111 (49.6) | 667 (49.9) | |
| ≥ 60 years | 557 (50.0) | 113 (50.4) | 670 (50.1) | |
| Stage | 0.41 | |||
| 0 | 2 (0.2) | 1 (0.6) | 3 (0.3) | |
| 1 | 2781 (33.5) | 56 (32.2) | 334 (33.2) | |
| 2 | 464 (55.8) | 105 (60.3) | 569 (56.6) | |
| 3 | 80 (9.6) | 12 (6.9) | 92 (9.2) | |
| 4 | 7 (0.8) | 7 (0.7) | 0 | |
| Grade | 0.11 | |||
| 1 | 89 (8.3) | 13 (6.0) | 102 (7.9) | |
| 2 | 405 (37.7) | 70 (32.4) | 475 (36.8) | |
| 3 | 580 (54.0) | 133 (61.6) | 713 (55.3) | |
| Histology | 0.006 | |||
| Ductal | 830 (75.1) | 191 (86.0) | 1021 (76.9) | |
| Lobular | 96 (8.7) | 10 (4.5) | 106 (8.0) | |
| Mixed | 128 (11.6) | 16 (7.2) | 144 (10.9) | |
| Others | 51 (4.6) | 5 (2.3) | 56 (4.2) | |
| ER | 0.006 | |||
| Positive | 799 (71.8) | 140 (62.5) | 939 (70.2) | |
| Negative | 314 (28.2) | 84 (37.5) | 398 (29.8) | |
| PR | 0.16 | |||
| Positive | 529 (47.5) | 95 (42.4) | 624 (46.7) | |
| Negative | 584 (52.5) | 129 (57.6) | 713 (53.3) | |
| HER2 | 0.24 | |||
| Positive | 168(15.1) | 27(12.1) | 195(14.6) | |
| Negative | 945(84.9) | 197(87.9) | 1,142(85.6) | |
| Relapse | 0.003 | |||
| No | 677(60.9) | 112(50.0) | 789(59.1) | |
| Yes | 435(39.1) | 112(50.0) | 547(40.9) | |
| Death | 0.001 | |||
| No | 522(46.9) | 78(34.8) | 600(44.9) | |
| Yes | 591(53.1) | 146(65.2) | 737(55.1) | |
| Cytolytic activity | < 0.0001 | |||
| CYT score | 6.9 (0.7) | 6.3 (0.6) | 6.8 (0.8) | |
*Student’s T-test, Pearson’s Chi-squared test, or Fisher’s exact test where appropriate.
Significant values are in bold.