Table 1.
Signaling pathways affected by loss of Appl
| Gene ontology term | p-value | z-score | Combined Score | Genes |
|---|---|---|---|---|
| TGFβ/BMP signaling | 1.39E-06 | −675.7 | 9113.1 | babo;kn;mei-P26;nkd;cv-c;Cip4;Vap33;put;nmo;Actbeta;scrib;bsk;Rac1;Wnt4;eIF4A |
| Ras protein signal transduction | 0.0001 | −535.8 | 4743 | hid;jeb;S6k;RyR;Octbeta3R;aPKC;Graf;crb;RhoGEF2;scrib;Eip93F;bsk;cic |
| Hippo signaling | 0.0008 | −546.7 | 3890.4 | crb;sas;cbt;rin;Actbeta;Nedd4;scrib;aPKC;bsk;cic |
| ERBB signaling | 0.003 | −543.7 | 3185.5 | Graf;sas;Syx1A;Tl;Eip93F;emc;Vav;bsk;Rac1;dock;cic |
| Wnt signaling | 0.008 | −469.7 | 2255.8 | Frl;bsk;Ssdp;Galphao;Wnt4 |
| Glutamate receptor signaling | 0.0046 | −411.4 | 2209.1 | Syt4;SPR;Actbeta;cv-c;CASK;mGluR |
| TORC1 signaling | 0.001 | −320.6 | 2056.6 | rin;Eip93F;bsk;Lpin;eIF4A |
| Notch signaling | 0.0001 | −190.0 | 1650.4 | Rbfox1;ct;crb;pros;heph;Nedd4;scrib;mam;emc;aPKC;bsk |
| G-protein coupled glutamate receptor signaling | 0.012 | −372.6 | 1628.2 | SPR;mGluR |
| calcium-mediated signaling | 0.02 | −253.6 | 988.5 | Fife;Piezo;RyR |
Signaling pathways identified through the gene ontology analysis of neuron-specific genes altered in Appl mutant flies categorized under biological process. Gene ontology was performed using FlyEnrichr. Gene ontology terms identified as signaling pathways with p-value < 0.05 are listed. The combined score is calculated by multiplying the p-value and z-score: c = ln(p) * z. The p-value is computed using Fisher’s exact test, a binomial proportion test assuming a binomial distribution.