Fig. 3.

Potential cutoffs of CGM-derived metrics for women with GDM. (A) ROC curves show the performance of TAR or daily MBG for predicting LGA, NICU admission or any adverse pregnancy outcome. AUC (95% CI) and optimal threshold of CGM-metric in each model were presented. The optimal threshold was determined by maximizing the Youden index. (B) Absolute risk was calculated as (No. of women with adverse outcome/No. of women in daily MBG category) × 100. The symbols represent the absolute risk for women in different daily MBG categories. Each daily MBG category was 5 mg/dl. The ORs (95% CI) were generated from the logistic regression to assessed associations of daily MBG in 5 mg/dl units with pregnancy outcomes. Any adverse pregnancy outcome was defined as the prevalence of one or more of the following conditions: preterm birth, LGA, fetal distress, premature rupture of fetal membranes, and NICU admission. Abbreviations: CGM, continuous glucose monitoring; ROC, receiver operating characteristic; TAR, time above range; MBG, mean blood glucose; LGA, large for gestational age; NICU, neonatal intensive care unit; AUC, the ROC area under the curve; OR, odds ratio; CI, confidence interval.