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. 2023 Sep 22;10(31):2304632. doi: 10.1002/advs.202304632

Figure 7.

Figure 7

Increased radiolabeled glucose uptake occurs in the polylactide (PLA) microenvironment and drives inflammation in vivo. a) When normalized to heart values, percent injected dose per gram (%ID g−1) of biopsied tissues surrounding amorphous PLA (aPLA) implants show higher F‐18 fluorodeoxyglucose (FDG) uptake compared to sham controls; increased FDG uptake is reduced by incorporation of 2‐deoxyglucose (2DG). b,c) Compared to sham controls, mean fluorescence intensity of CD11b (b) or F4/80 (c) is increased following surgical implantation of aPLA or a combination of aPLA and hydroxyapatite (HA), but not a combination of aPLA and 2DG. d) Compared to other groups, CD206 mean fluorescence intensity is increased in aPLA + HA. e) Compared to sham controls, CD86 mean fluorescence intensity is increased following implantation of aPLA; elevated CD86 is decreased by incorporating 2DG but not HA. Mean (SD); Figure 1a, sham (n = 12), aPLA (n = 8), aPLA + 2DG (n = 10); Figure 1b–e, sham (n = 15), aPLA (n = 15), aPLA + 2DG (n = 15), aPLA + HA (n = 10); one‐way ANOVA followed by Tukey's post‐hoc test or Brown–Forsythe and Welch ANOVA followed by Dunnett's T3 multiple comparison test; refer to Experimental Section (in vivo studies, tissue processing and analyses) for more information on n.