Table 3.
Pathway enrichment analysis of metabolites associated with quantitative interstitial abnormalities
| Pathway* | Total in pathway | Hits | FDR p-value |
Pathway impact value | |
|---|---|---|---|---|---|
| Nicotinate and nicotinamide metabolism | 15 | 1 | Quinolinate | 6.81E−11 | 0 |
| Histidine metabolism | 16 | 1 | Methylimidazoleacetic acid | 5.61E−09 | 0 |
| Starch and sucrose metabolism | 18 | 2 | Sucrose; Maltose | 2.14E−07 | 0.123 |
| Glycerophospholipid metabolism | 36 | 2 | Phosphatidylcholine (PC); 1-Acyl-sn-glycero-3-phosphocholine (Lysophosphatidylcholine, LPC) | 7.83E−0 | 0.112 |
| Pyrimidine metabolism | 39 | 2 |
3-Ureidopropionate; Cytidine |
1.81E−05 | 0.020 |
| Galactose metabolism | 27 | 1 | Sucrose | 1.50E−04 | 0.039 |
| Pentose and glucuronate interconversions | 18 | 1 | D-Xylose | 2.11E−04 | 0.078 |
| Arginine and proline metabolism | 38 | 1 | N-Acetylputrescine | 2.77E−04 | 0.023 |
| Pantothenate and CoA biosynthesis | 19 | 2 |
3-Ureidopropionate; 3-Methyl-2-oxobutanoic acid |
4.05E−04 | 0.029 |
| Sphingolipid metabolism | 21 | 2 | Sphingomyelin; Sphingosine | 4.60E−04 | 0.045 |
| beta-Alanine metabolism | 21 | 1 | 3-Ureidopropionate | 6.93E−04 | 0.104 |
| Arachidonic acid metabolism | 36 | 1 | Phosphatidylcholine (PC) | 8.32E−04 | 0 |
| Linoleic acid metabolism | 5 | 1 | Phosphatidylcholine (PC) | 8.32E−04 | 0 |
| Primary bile acid biosynthesis | 46 | 1 | Taurochenodeoxycholate | 0.009 | 0.010 |
| Valine, leucine and isoleucine degradation | 40 | 1 | 3-Methyl-2-oxobutanoic acid | 0.02 | 0.011 |
| Cysteine and methionine metabolism | 33 | 2 | (S)-2-Aminobutanoate; 2-Oxobutanoate | 0.02 | 0.102 |
| Valine, leucine and isoleucine biosynthesis | 8 | 2 |
3-Methyl-2-oxobutanoic acid; 2-Oxobutanoate |
0.07 | 0 |
| Arginine biosynthesis | 14 | 1 | Citrulline | 0.10 | 0.228 |
| Propanoate metabolism | 23 | 1 | 2-Oxobutanoate | 0.10 | 0.041 |
| Glycine, serine and threonine metabolism | 33 | 1 | 2-Oxobutanoate | 0.10 | 0 |
| Tyrosine metabolism | 42 | 1 | Thyroxine | 0.12 | 0 |
| alpha-Linolenic acid metabolism | 13 | 2 | Phosphatidylcholine (PC); Stearidonic acid | 0.19 | 0 |
| Biosynthesis of unsaturated fatty acids | 36 | 3 |
Octadecanoic acid; Docosahexaenoic acid; Icosapentaenoic acid |
0.27 | 0 |
| Fatty acid biosynthesis | 47 | 1 | Tetradecanoic acid | 0.36 | 0 |
Abbreviations: FDR = Benjamini–Hochberg False Discovery Rate
*Metabolites with a Human Metabolome Database (HMDB) ID number