Table 3.

Mathematical modeling and release kinetics of the prepared FST-loaded LPHNPs (F3) and uncoated one (F1) as well as aqueous FST dispersion (S1) and FST/Tris aqueous solution (S2) (see Table 1 for F1 & F3 composition). (R²): Coefficient of determination, (n): Diffusional exponent, (β): shape parameter.

Formula code	Zero-order (R2)	First-order (R2)	Higuchi-diffusion model (R2)	Korsmeyer-Peppas equation		Mechanism of release	Weibull
				(R2)	(n)		(R2)	(β)
F3 in (pH 1.2)	0.6292	0.6645	0.8408	0.8635	0.5076	Fickian	0.8743	0.6293
F3 in (pH 6.8)	0.5851	0.6261	0.8046	0.8808	0.3626	Fickian	0.8878	0.3971
F3 in (pH 7.4)	0.6169	0.6815	0.8485	0.9265	0.3753	Fickian	0.9367	0.4258
F1 in (pH 1.2)	0.6274	0.6787	0.8461	0.8926	0.4906	Fickian	0.9048	0.5324
F1 in (pH 6.8)	0.5978	0.6618	0.8177	0.8666	0.3385	Fickian	0.8783	0.3817
F1 in (pH 7.4)	0.5803	0.6598	0.8204	0.9023	0.3193	Fickian	0.9145	0.3752
S1 in (pH 1.2)	0.2371	0.2360	0.4065	0.5210	0.3540	Fickian	0.5208	0.3632
S1 in (pH 6.8)	0.2751	0.2766	0.4949	0.6858	0.4245	Fickian	0.6865	0.4350
S1 in (pH 7.4)	0.2333	0.2347	0.4358	0.5937	0.2532	Fickian	0.5919	0.2620
S2 in (pH 1.2)	0.3060	0.3571	0.5681	0.9724	0.4148	Fickian	0.7807	0.5704
S2 in (pH 6.8)	0.2693	0.3302	0.5290	0.9844	0.3407	Fickian	0.7666	0.5111
S2 in (pH 7.4)	0.2369	0.3424	0.4908	0.9866	0.2944	Fickian	0.7587	0.5542