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. 2023 Nov 4;13:19055. doi: 10.1038/s41598-023-45774-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Glioma subtype based on the glioma up-regulated MAPK signaling pathway gene set. The glioma up-regulated MAPK signaling pathway gene set was used to cluster C1/C2 and assign a prognosis. TCGA data were used to calculate all analyses in this figure. (A) Consensus CDF plot of subtype numbers (k = 2–6). (B) Delta area plot of the consensus CDF plot. (C) Cluster trees and consensus matrix of subtypes. (D) PCA plot of the consensus clustering. (E) survival KM plots of the subtypes. (F) Overall survival KM plot of the MAPK subtypes within histologic subtypes. The “ggplot2” package was utilized to plot the figures with R software.