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. 2023 Nov 4;13:19085. doi: 10.1038/s41598-023-46415-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Covariation of tTRE transcription as an indicator of correlated interactions. (a) High-resolution example of the co-expression analysis strategy at the SLFN5 locus. The PRO-cap signal at each variably expressed tTRE (proximal enhancer or promoter; grey box) is correlated with the PRO-cap signal of each other variably expressed tTRE in the vicinity, across LCL samples. The lower panel shows the corresponding heatmap of the Hi-C contact matrix with a resolution of 1 kilobase. (b) Coexpression over a larger region at the BCL2 locus reveals putative correlated interactions both within and between tTRE clusters (grey box: BCL2 super-enhancer). Heatmap shows correlation coefficients for correlations between tTRE pairs across LCL samples. The lower panel shows the corresponding heatmap of the Hi-C contact matrix with a resolution of 1 kb. The regions of high interaction are highlighted with a circle and three triangles, each representing a different interaction.