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. Author manuscript; available in PMC: 2023 Nov 5.
Published in final edited form as: Biochem Soc Trans. 2023 Aug 31;51(4):1447–1458. doi: 10.1042/BST20220845

Figure 4. NosP signaling in V. cholerae.

Figure 4.

A. The NosP domain of CdpA is required for bacterial attachment in V. cholerae. Inhibition of the PDE activity of CdpA contributes to an accumulation of c-di-GMP which binds to MSHA pili. This allows for the pili to extend and promotes bacterial attachment. B. In the presence of NO, the NosP domain will promote PDE activity of CdpA contributing to pili retraction and bacterial detachment. C. The NosP (VpsV) and VpsS signaling cascade in the LuxU QS circuit. When NosP ligates ferrous NO, it inhibits VpsS, preventing VpsS from phosphorylating LuxU. This prevents QS signaling that leads to biofilm formation; overall, inactivation of VpsS promotes biofilm dispersal. Yellow parallelogram - heme, nitrogen - blue, oxygen - red.62