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. Author manuscript; available in PMC: 2023 Nov 5.
Published in final edited form as: Eur J Pharm Sci. 2018 Jan 12;115:88–99. doi: 10.1016/j.ejps.2018.01.021

Figure 2.

Figure 2.

Inhibition of 5-oxo-ETE-induced granulocyte activation by 264. A: Histograms showing F-actin levels in eosinophils, measured by flow cytometry, following incubation of leukocytes with either vehicle (green; light grey fill), 5-oxo-ETE (10 nM; blue; dark grey fill) or 5-oxo-ETE (10 nM) in the presence of 300 nM 264 (red; no fill). B: Concentration-response curves for the inhibition of actin polymerization in response to 5-oxo-ETE (10 nM) in monkey (●) and human (○) eosinophils. C: Concentration-response curves for the inhibition of the chemotactic response to 5-oxo-ETE (100 nM) in monkey (●) and human (○) leukocytes. The data for human cells were taken from ref. 12 for comparison.