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. Author manuscript; available in PMC: 2023 Nov 5.
Published in final edited form as: Eur J Pharm Sci. 2018 Jan 12;115:88–99. doi: 10.1016/j.ejps.2018.01.021

Figure 7.

Figure 7.

Mass spectra of 264 metabolites. Metabolites were first purified by RP-HPLC as shown in Fig. 5 and then analyzed by LC/MS/MS using negative ion ESI except for metabolite a (panels C and D), in which case positive ion ESI was used. A: MS2 fragmentation of the [M-H]− ion at m/z 378 of c isolated from monkey liver microsomes. B: MS3 fragmentation of m/z 250 from panel A. C: MS2 of the [M+H]+ ion at m/z 378 for metabolite a, isolated from liver microsomes. D: MS3 fragmentation of the ion at m/z 250 in panel C. E: MS2 of the [M-H]− ion at m/z 392 for metabolite b, isolated from monkey plasma. F: MS2 fragmentation of the ion at m/z 264 in panel E. G: MS2 of the [M-H]− ion at m/z 364 for metabolite e from plasma. H: MS2 of the [M-H]− ion at m/z 394 for metabolite d isolated from plasma. I: MS2 of the [M-H]− ion at m/z 234 of metabolite f from plasma.