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. Author manuscript; available in PMC: 2023 Nov 5.
Published in final edited form as: Eur J Pharm Sci. 2018 Jan 12;115:88–99. doi: 10.1016/j.ejps.2018.01.021

Figure 9.

Figure 9.

Effects of 264 metabolites on 5-oxo-ETE-induced calcium mobilization in human neutrophils. Intracellular calcium levels were measured in indo-1-loaded neutrophils treated with 264 or one of its synthetic metabolites followed 2 min later by addition of 5-oxo-ETE (10 nM). All compounds are racemic mixtures: 264 (■), ω1-hydroxy-264 (▲, ω-OH); ω-carboxy-264 (△, ωC), dinor-ω-carboxy-264 (▽, dn), ω2-hydroxy-264 (●, ω2-OH), ω2-oxo-264 (○, oxo). Values are means ± SE of data from 4 to 5 independent experiments.