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. 2023 Jul 20;7(20):6367–6380. doi: 10.1182/bloodadvances.2023010817

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© 2023 by The American Society of Hematology. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved.

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Figure 7. — Schematic diagram of complement-induced prothrombotic phenotype. Strong proximal complement activation culminates in terminal pathway activation liberating C5a and inducing MAC assembly. Although C5a is liberated in C3G, PNH, aHUS, and autoimmune hemolytic anemia (AIHA), cytolytic MAC complexes are reported for the latter 3 but not C3G. MAC-mediated release of the intracellular danger signal ADP induces prothrombotic activation states of platelets and endothelial cells, culminating in thrombosis. Potential therapeutic intervention strategies are shown in red. Elements in bold font depict concepts derived from data of this study. The illustration was created with BioRender.com.