Table 1.
The distribution of mutations and neoantigens across 16 tumor types
| Mutation type | Tissue | No. of samples | No. of mutations | No. of neoantigens | No. of neoantigens per mutation |
|---|---|---|---|---|---|
| SNV | Bladder | 408 | 74,707 | 21,070 | 0.38 |
| Brain | 151 | 16,197 | 5227 | ||
| Breast | 982 | 62,211 | 18,238 | ||
| Cervix | 286 | 46,607 | 11,906 | ||
| Colorectal | 531 | 165,293 | 39,116 | ||
| Head and neck | 495 | 55,968 | 13,728 | ||
| Kidney | 681 | 26,170 | 8499 | ||
| Liver | 358 | 28,024 | 5987 | ||
| Lung | 999 | 212,861 | 52,801 | ||
| Ovary | 305 | 28,478 | 7631 | ||
| Pancreas | 166 | 17,221 | 3985 | ||
| Prostate | 493 | 16,424 | 5363 | ||
| Skin | 466 | 206,907 | 43,882 | ||
| Stomach | 411 | 103,103 | 24,497 | ||
| Thyroid | 488 | 4425 | 1218 | ||
| Uterus | 528 | 415,499 | 109,125 | ||
| INDEL | Bladder | 389 | 2890 | 3532 | 1.22 |
| Brain | 130 | 366 | 375 | ||
| Breast | 888 | 5207 | 6123 | ||
| Cervix | 257 | 3095 | 4234 | ||
| Colorectal | 520 | 21,327 | 29,876 | ||
| Head and neck | 478 | 3569 | 4913 | ||
| Kidney | 648 | 5318 | 6395 | ||
| Liver | 353 | 2120 | 2143 | ||
| Lung | 983 | 10,790 | 12,407 | ||
| Ovary | 296 | 4260 | 4441 | ||
| Pancreas | 141 | 457 | 806 | ||
| Prostate | 416 | 1448 | 2119 | ||
| Skin | 430 | 1965 | 2557 | ||
| Stomach | 393 | 19,912 | 24,838 | ||
| Thyroid | 248 | 1746 | 1657 | ||
| Uterus | 516 | 27,934 | 30,714 | ||
| Fusion | Bladder | 269 | 809 | 819 | 0.88 |
| Brain | 92 | 244 | 245 | ||
| Breast | 787 | 3390 | 3457 | ||
| Cervix | 139 | 280 | 215 | ||
| Colorectal | 167 | 328 | 231 | ||
| Head and neck | 285 | 532 | 530 | ||
| Kidney | 171 | 318 | 420 | ||
| Liver | 179 | 513 | 423 | ||
| Lung | 716 | 1992 | 710 | ||
| Ovary | 316 | 983 | 609 | ||
| Pancreas | 72 | 130 | 161 | ||
| Prostate | 381 | 1079 | 1120 | ||
| Skin | 287 | 841 | 918 | ||
| Stomach | 178 | 559 | 486 | ||
| Thyroid | 110 | 140 | 250 | ||
| Uterus | 85 | 501 | 499 | ||
Note: SNV, single nucleotide variant; INDEL, insertion/deletion; Fusion, gene fusion.