Figure 7.
Association between trait-associated genes and cell type-specific genes
Fifty-one traits were analyzed. Heatmap shows the significant trait–tissue associations (P < 0.05). The numbers on the cells indicate the shared gene counts between TAGs and CTGenes in BlueprintEncode. The colors and sizes represent the shared gene counts and the log10-transformed P values. Since more significant SNPs are likely found in immune-related diseases and blood-related traits than other traits, we recommend users to focus on the top 3 most relevant cell types for those traits with higher TAG number. Names of cell types on Y-axis are derived from original references. SNP, single nucleotide polymorphisin; TAG, trait-associated gene; CLP, common lymphoid progenitor; MPP, multipotent progenitor cell; ALZ, Alzheimer's disease; ADHD, attention deficit-hyperactivity disorder; ASD, autism spectrum disorder; BIP, bipolar disorder; MDD, major depressive disorder; SCZ, schizophrenia; ANXC_FS, anxiety angst; DS, depressive symptoms; NRT, neuroticism; OCD, obsessive-compulsive disorder; PTSD, post-traumatic stress disorder; SWB, subjective well-being; ATH, asthma; CAD, coronary artery disease; MIGR, migraine; T2D, type 2 diabetes; CD, Crohn’s disease; CEL, celiac disease; IBD, inflammatory bowel disease; MS, multiple sclerosis; PBC, primary biliary cholangitis; RA, rheumatoid arthritis; SLE, systemic lupus erythematosus; T1D, type 1 diabetes; UC, ulcerative colitis; BFP, body fat percentage; BMI, body mass index; BW, birthweight; COL, college; CPD, cigarettes per day; EDU, education; FN-BMD, bone mineral density (femoral neck); HEIGHT, height; LS-BMD, bone mineral density (lumbar spine); RHR, resting heart rate; WHR, waist–hip ratio; 2HG, two-hour glucose; AAM, age at menarche; EGFR, glomerular filtration rate; FG, fasting glucose; FI, fasting insulin; HDL, high-density lipoprotein; LDL, low-density lipoprotein; TC, total cholesterol; TG, triglyceride; MCH, mean cell hemoglobin; MCHC, mean cell hemoglobin concentration; MCV, mean red blood cell volume; MPV, mean platelet volume; PLT, platelet count; RBC, red blood cell count.