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. Author manuscript; available in PMC: 2023 Nov 5.
Published in final edited form as: Circ Arrhythm Electrophysiol. 2020 Jul 6;13(8):e006875. doi: 10.1161/CIRCEP.118.006875

Figure 4.

Figure 4.

GS967 accelerates Ca2+ transient decay in LQT2 in the presence of 50 nM ISO. A) Representative Ca2+ transients recorded from isolated cardiac myocytes before (black) and after (red) 100 nM GS967 at CL = 2000 ms. B) Ca2+ transient decay at 0.5 Hz. (τ75=523.8±35.0 vs. 300.7±19.3 for 0 and 100 nM GS967 respectively. N=20 cells from 3 LQT2 hearts in each group, p < 0.05). C-D) Caffeine-induced Ca2+ release and its decay. GS967 (red) accelerated Ca2+ decay (τ50 =1.051±0.179 vs. 0.540±0.070 s for 0 and 100 nM GS967 respectively. n=9 and 14 cells from 3 LQT2 hearts. p<0.05).