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. Author manuscript; available in PMC: 2023 Nov 5.
Published in final edited form as: Circ Arrhythm Electrophysiol. 2020 Jul 6;13(8):e006875. doi: 10.1161/CIRCEP.118.006875

Table 1.

APD and CV in the absence and presence of GS967 at CL = 350 ms and 250 ms in LQT2 rabbits.

0 nM 30 nM 100 nM
CL 350 ms 250 ms 350 ms 250 ms 350 ms 250 ms
APD (ms) 221±23 197 ± 12 237±27 203±15 227±31 201±8
CV (m/s) 0.75±0.06 0.68±0.04 0.75±0.03 0.64±0.03 0.74±0.03 0.59±0.06*

Values are mean ± STDEV obtained from 7 hearts. APDs were not affected by GS967, but CVs were modestly reduced (13%) at fast CL (250 ms) by 100 nM GS967 (n=7, * indicates paired t-test, p<0.05 between 0 nM and 100 nM at CL=250 ms).