Table 1.
Baseline characteristics Stratified by the groups with and without AAAa
| Variables | Unmatched population | Matched population | ||||||
|---|---|---|---|---|---|---|---|---|
| Normal (n = 9340) | AAA (n = 219) | SMD | P† | Normal (n = 219) | AAA (n = 219) | SMD | P† | |
| Age (years) | 70.3 ± 0.1 | 72.6 ± 0.4 | 0.345 | < 0.001 | 72.6 ± 0.5 | 72.6 ± 0.4 | 0.004 | 0.946 |
| BMI (Kg/m2) | 23.9 ± 0.03 | 23.8 ± 0.2 | 0.043 | 0.507 | 24.0 ± 0.2 | 23.8 ± 0.2 | 0.098 | 0.583 |
| Sex (male) | 63.7 (5949) | 89.0 (195) | 0.625 | < 0.001 | 92.2 (202) | 89.0 (195) | 0.110 | 0.251 |
| Smoking, % | 23.7 (2216) | 40.2 (88) | 0.358 | < 0.001 | 37.4 (82) | 40.2 (88) | 0.056 | 0.556 |
| Hypertension, % | 54.0 (5047) | 66.7 (146) | 0.260 | < 0.001 | 66.2 (145) | 66.7(146) | 0.010 | 0.919 |
| Diabetes mellitus, % | 21.6 (2013) | 18.7 (41) | 0.071 | 0.313 | 15.1 (33) | 18.7 (41) | 0.097 | 0.308 |
| Coronary artery disease, % | 38.8 (3627) | 56.2 (3750) | 0.352 | < 0.001 | 53.0 (116) | 56.2 (123) | 0.064 | 0.502 |
| Peripheral artery disease, % | 3.3(312) | 3.7(8) | 0.017 | 0.799 | 5.0 (11) | 3.7 (8) | 0.067 | 0.482 |
| Stroke, % | 5.4(503) | 10.0(22) | 0.175 | 0.003 | 9.6 (21) | 10.0 (22) | 0.015 | 0.872 |
| Maximal abdominal aortic diameter (mm) | 19.0 (17.0–20.5) | 36.0 (32.0–47.0) | 2.317 | < 0.001 | 20.0 (18.0–21.0) | 36.0 (32.0–47.0) | 2.303 | < 0.001 |
| ALT (U/L) | 20.0 (14.7–27.7) | 18.0 (14.0–25.0) | 0.060 | 0.003 | 21.0 (16.0–27.4) | 18.0 (14.0–25.0) | 0.214 | < 0.001 |
| AST (U/L) | 22.0 (18.3–28.0) | 21.0 (18.7–27.5) | 0.015 | 0.407 | 22.9 (19.0–28.4) | 21.0 (18.7–27.5) | 0.087 | 0.069 |
| UA (mmol/L) | 398.0 (327.9–460.0) | 422.0 (368.0–504.3) | 0.332 | < 0.001 | 402.0 (351.3–483.3) | 422.0 (368.0–504.3) | 0.234 | 0.006 |
| CR (μmol/L) | 81.0 (67.0–96.8) | 94.9 (77.7–118.3) | 0.328 | < 0.001 | 89.2 (75.1–105.0) | 94.9 (77.7–118.3) | 0.154 | 0.010 |
| BUN (mmol/L) | 5.5 (4.5–6.9) | 6.2 (5.2–8.2) | 0.320 | < 0.001 | 5.9 (4.6–7.3) | 6.2 (5.2–8.2) | 0.141 | 0.106 |
| TG (mmol/L) | 1.4 (1.0–1.9) | 1.4 (1.0–1.7) | 0.087 | 0.912 | 1.4 (1.0–1.9) | 1.4 (1.0–1.7) | 0.039 | 0.245 |
| TC (mmol/L) | 4.6 (3.8–5.4) | 4.6 (3.7–5.3) | 0.076 | 0.265 | 4.1 (3.5–5.2) | 4.6 (3.7–5.3) | 0.216 | 0.034 |
| LDL- C (mmol/L) | 2.8 (2.2–3.5) | 2.9 (2.3–3.5) | 0.060 | 0.250 | 2.6 (2.0–3.3) | 2.9 (2.3–3.5) | 0.293 | 0.002 |
| HDL-C (mmol/L) | 1.1 (1.0–1.4) | 1.0 (0.9–1.2) | 0.102 | < 0.001 | 1.1 (0.9–1.3) | 1.0 (0.9–1.2) | 0.206 | 0.049 |
| non-HDL-C (mmol/L) | 3.4 (2.7–4.2) | 3.6 (2.8–4.2) | 0.102 | 0.114 | 3.1 (2.5–3.9) | 3.6 (2.8–4.2) | 0.343 | 0.001 |
| non-HDL-C / HDL-C ratio | 2.9 (2.2–3.8) | 3.5 (2.9–4.3) | 0.457 | < 0.001 | 3.0 (2.3–3.8) | 3.5 (2.9–4.3) | 0.449 | < 0.001 |
| Fasting glucose (mmol/L) | 5.3 (4.7–6.3) | 5.2 (4.5–6.6) | 0.088 | 0.109 | 5.3 (4.6–6.2) | 5.2 (4.5–6.6) | 0.107 | 0.197 |
| HBA1C (mmol/L) | 6.1 (5.7–6.3) | 6.0 (5.6–6.2) | 0.273 | < 0.001 | 6.1 (5.8–6.2) | 6.0 (5.6–6.2) | 0.236 | 0.021 |
| Medication use | ||||||||
| Angiotensin system inhibitors, % | 47.5 (4439) | 56.6 (124) | 0.183 | 0.008 | 54.3 (119) | 56.6 (124) | 0.046 | 0.631 |
| Beta-blockers, % | 42.1 (3932) | 62.6 (137) | 0.418 | < 0.001 | 58.0 (127) | 62.6 (137) | 0.093 | 0.329 |
| Statins, % | 51.0 (4762) | 67.1 (147) | 0.332 | < 0.001 | 65.8 (144) | 147.0 (67.1) | 0.029 | 0.761 |
| Metformin, % | 9.6 (895) | 7.8 (17) | 0.065 | 0.365 | 7.8 (17) | 7.8 (17) | < 0.001 | 1.000 |
Abbreviations: AAA Abdominal aortic aneurysm, BMI Body mass index, ALT Alanine aminotransferase, AST aspartate aminotransferase, UA Uric acide, Cr Creatinine, BUN Blood urea nitrogen, TG Triglyceride, TC Total cholesterol, LDL-C Low-density lipoprotein cholesterol, HDL-C High-density lipoprotein cholesterol, non-HDL-C Non-high-density lipoprotein cholesterol, non-HDL-C/HDL-C ratio Non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio, HbA1c Hemoglobin A1c, SMD Standardized mean difference
aValues are given as mean + standard deviation, number (percentage), or median (quartiles 1 through 3). †P-values were derived from Mann–Whitney U-tests for continuous variables, and Chi-square tests for categorical variables