Table 2.

Associations between physical activity, neuroticism, and global cognitive function and decline

	Model 1			Model 2			Model 3			Model 4
Participants	7613			7626			7608			7608
Total observations	25,338			25,372			25,327			25,327
	β	SE	p-value	β	SE	p-value	β	SE	p-value	β	SE	p-value
Intercept	0.493	0.014	0.000	0.464	0.018	0.000	0.478	0.018	0.000	0.484	0.018	0.000
Time	-0.049	0.002	0.000	-0.054	0.003	0.000	-0.053	0.003	0.000	-0.053	0.003	0.000
Age	-0.034	0.001	0.000	-0.034	0.001	0.000	-0.034	0.001	0.000	-0.034	0.001	0.000
Age*time	-0.004	0.000	0.000	-0.004	0.000	0.000	-0.004	0.000	0.000	-0.004	0.000	0.000
Sex	-0.124	0.013	0.000	-0.108	0.013	0.000	-0.126	0.013	0.000	-0.126	0.013	0.000
Sex*time	0.006	0.002	0.004	0.006	0.002	0.004	0.005	0.002	0.010	0.005	0.002	0.010
Race	-0.358	0.014	0.000	-0.354	0.015	0.000	-0.355	0.014	0.000	-0.355	0.014	0.000
Race*time	-0.001	0.002	0.540	-0.001	0.002	0.649	-0.001	0.002	0.730	-0.001	0.002	0.724
Education	0.062	0.002	0.000	0.066	0.002	0.000	0.062	0.002	0.000	0.062	0.002	0.000
Education*time	-0.001	0.000	0.123	0.000	0.000	0.184	-0.001	0.000	0.095	-0.001	0.000	0.083
Medical conditions	0.009	0.006	0.165	0.004	0.006	0.525	0.009	0.006	0.164	0.009	0.006	0.155
Medical conditions*time	-0.002	0.001	0.042	-0.002	0.001	0.042	-0.002	0.001	0.058	-0.002	0.001	0.055
CESD	-0.010	0.003	0.000	-0.018	0.003	0.000	-0.010	0.003	0.000	-0.010	0.003	0.000
CESD*time	-0.002	0.000	0.000	-0.002	0.000	0.000	-0.002	0.000	0.000	-0.002	0.000	0.000
Neuroticism	-0.036	0.003	0.000				-0.035	0.003	0.000	-0.046	0.005	0.000
Neuroticism*time	-0.001	0.001	0.211				-0.001	0.001	0.259	0.000	0.001	0.642
Medium PA				0.030	0.016	0.054	0.023	0.016	0.134	0.015	0.016	0.343
High PA				0.029	0.016	0.069	0.017	0.016	0.280	0.010	0.016	0.547
Medium PA*time				0.003	0.003	0.208	0.003	0.003	0.236	0.004	0.003	0.159
High PA*time				0.006	0.003	0.018	0.006	0.003	0.028	0.006	0.003	0.017
Medium PA*neuroticism										0.013	0.007	0.060
High PA*neuroticism										0.017	0.007	0.010
Medium PA*neuroticism*time										-0.001	0.001	0.319
High PA*neuroticism*time										-0.002	0.001	0.189

Time is reported in years

Models adjusted for age, sex, race, education, medical conditions, CESD, and each of their interactions with time

Medium PA Medium Physical Activity, High PA High Physical Activity, CESD Modified Center for Epidemiologic Studies-Depression Scale

* refers to interaction