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. Author manuscript; available in PMC: 2024 Jun 1.
Published in final edited form as: Nat Struct Mol Biol. 2023 May 25;30(6):824–833. doi: 10.1038/s41594-023-00991-z

Fig. 1|. Cryo-EM structures of the human TSEN complex.

Fig. 1|

Cryo-EM reconstructions of: a. wt-TSEN•pre-tRNA and b. endoX-TSEN•pre-tRNA, with cartoon overlays below. Due to its improved resolution, the endoX reconstruction was used to build and refine the overall structure. c. Model of the human TSEN complex at 0° and 90°, with overall dimensions of 116 × 79 × 65 Å. The subunits are colored as follows: TSEN54 (teal), TSEN34 (pink), TSEN2 (orange), TSEN15 (blue). The pre-tRNA is shaded in dark grey, with the intron in light grey.