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. Author manuscript; available in PMC: 2023 Nov 5.
Published in final edited form as: Exp Cell Res. 2020 Sep 26;396(2):112300. doi: 10.1016/j.yexcr.2020.112300

Figure 2: Regulatory principles underlying CRL3 function and substrate recruitment.

Figure 2:

A) Scheme depicting how signal-induced posttranslational modification (PTMs, e.g. phosphorylation, glycosylation, cysteine modifications) of BTB adaptors or substrates can promote or inhibit interaction and thus CRL3 function. B) Model of a homo-dimeric CRL3 complex highlighting the different mechanisms how dimerization is thought to regulate CRL3 function.