Table 2.

Univariate and multivariable analysis for overall survival (all patients).

Variables		Univariate analysis			Multivariate analysis
		HR	95% CI	P	HR	95% CI	P
Sex	Male	1			1
	Female	3.539	1.624 - 7.320	0.0009	4.526	1.934 - 10.18	0.0003
Age	≥60	1			1
	<60	1.879	0.9796 - 3.849	0.0680	1.735	0.8321 - 3.847	0.1551
Primary site	Oral cancer	1			1
	Oropharyngeal cancer	0.8634	0.2535 - 2.237	0.2716	0.5177	0.1416 - 1.504	0.2633
	Laryngeal cancer	0.6493	0.2136 - 1.610	0.8551	0.6374	0.1841 - 1.888	0.4405
	Hypopharynx cancer	1.304	0.3082 - 3.762	0.4302	0.8184	0.1709 - 2.890	0.7750
	Nasal and sinus cancer	1.351	0.4972 - 3.121	0.6538	1.058	0.3693 - 2.606	0.9081
Tumor site	Local recurrence	1			1
	Distant metastasis	0.6940	0.2279 - 1.735	0.4715	0.5959	0.1702 - 1.719	0.3731
	Both	2.155	1.088 - 4.152	0.0234	1.795	0.8298 - 3.756	0.1266
Immunotherapy	Yes	1			1
	No	0.6337	0.2175 - 1.475	0.3400	0.5312	0.1757 – 1.319	0.2090
CDKN2A	WT	1			1
	LOF	2.114	1.154 - 3.973	0.0168	2.311	1.156 - 4.748	0.0194

HR, hazard ratio; CI, confidence interval; LOF, loss-of-function; WT, wild-type.