Skip to main content
. 2023 Oct 13;14:1260146. doi: 10.3389/fimmu.2023.1260146

Figure 3.

Figure 3

Cell-mediated–immunity (CMI) features associated with symptomatic RSV infection. Poisson regression analysis on all cell-mediated–immunity (CMI) features after data preprocessing identified eight CD4+ and 25 CD8+ T-cell populations that were differentially abundant between the RSV-Asymptomatic group (Asympt.) and the RSV-ARTI-4X subset (Sympt.; see Supplementary Table 1 ). The top five cell populations with the highest absolute fold differences are shown for (A) CD4+ T cells and (B) CD8+ T cells. Only subjects with T-cell data for CD4+ (N=11 and 11, respectively by group) or CD8+ (N=10 and 9, respectively by group) were used for the regression analysis. Fold differences were computed as the ratio of the means of values of symptomatic subjects and the values of asymptomatic subjects. Unadjusted P-values are also shown, although, adjusted P-values ≤0.05 set the threshold for those ratios to be included in the ranking (see Supplementary Table 1 ). RSV-ARTI 4X subset included those subjects in the RSV-ARTI group who had a ≥4-fold increase in RSV-specific antibody titers over the RSV season. 40L, CD40L; IL2, IL-2; TNF, TNF-α; IFN, IFN-γ; IL13, IL-13, IL17, IL-17; and 1BB, 4-1BB (CD137). Circular symbols describe individual values and horizontal lines describe means.