Figure 4.

Functional antibody features associated with symptomatic RSV infection. Student’s t-test identified three functional antibody features differing between RSV-ARTI-4X group (Sympt.; N=16) and RSV-Asymptomatic group (Asympt. N=16). Fold differences were computed as the ratio of the means of values of symptomatic subjects and the values of asymptomatic subjects, and the unadjusted P-values ≤0.05 set the threshold for those ratios to be included in the ranking. The three function features are (i) ADP by DCs leading to IL-8 signaling (ADDCP - IL8); (ii) antibody-dependent phagocytosis (ADP) by DCs leading to IP-10 signaling (ADDCP - IP10); and (iii) ADP by neutrophils (ADNP - Phagocytosis). The adjusted P-values (using the Benjamini-Hochberg multiple-test correction) were (i) 0.2, (ii) 0.1, and (iii) 0.1. Circular symbols describe individual values and horizontal lines describe means.